15 12 月, 2022

Eisai and Washington University School of Medicine in St. Louis Enter Into Comprehensive Research Collaboration Agreement Aiming to Create New Therapies for Neurodegenerative Diseases

TOKYO, Dec 15, 2022 - (JCN Newswire via SEAPRWire.com) - Eisai Co., Ltd. announced today that Eisai and Washington University School of Medicine in St. Louis have entered into a comprehensive research collaboration agreement aiming to create potential novel treatments for neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD).Washington University is world leading in research on prevention, diagnosis, biomarkers and treatment of neurodegenerative diseases. The two organizations have been collaborating in AD research. The Phase II/III Tau NexGen Study conducted by the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU), led by the University's School of Medicine, is exploring the safety, tolerability, biomarkers and cognitive efficacy of Eisai's anti-MTBR (microtubule binding region) tau antibody E2814 for the treatment of dominantly inherited Alzheimer's disease (DIAD). In this study, the anti-amyloid beta (Aβ) protofibril antibody lecanemab (generic name, development code: BAN2401) was selected as the background anti-amyloid agent.The collaboration strategically combines Washington University scientists" expertise in the fundamental and clinical research in neurodegenerative diseases, such as dementia, with Eisai's extensive experience in drug discovery and development. Using human biology, the aim is to create multiple novel therapeutic candidates as well as discover and identify biomarkers within the next five years. Eisai will have the option rights to develop and commercialize any compounds and biomarkers that meet certain criteria in terms of research and development milestones. In the case that Eisai chooses to exercise the options, Eisai will pay Washington University milestone payments and royalties on future sales of each licensed compounds.Dr. Teiji Kimura, Ph.D., Academia and Industry Alliance Officer, Deep Human Biology Learning (DHBL) Office of Eisai, commented, "Patients living with neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, struggle with critical unmet medical needs, which is the reason neurology is a key therapeutic area for Eisai. By collaborating with world-leading research institutions such as Washington University in St. Louis, Eisai is working to fulfill our human health care mission and provide potential new and targeted disease-modifying therapies with the ultimate goal of achieving a world free of neurodegenerative disease."About Washington University School of MedicineWashU Medicine is a global leader in academic medicine, including biomedical research, patient care and educational programs with 2,700 faculty. Its National Institutes of Health (NIH) research funding portfolio is the fourth largest among U.S. medical schools, has grown 54% in the last five years, and, together with institutional investment, WashU Medicine commits well over $1 billion annually to basic and clinical research innovation and training. Its faculty practice is consistently within the top five in the country, with more than 1,790 faculty physicians practicing at over 60 locations and who are also the medical staffs of Barnes-Jewish and St. Louis Children's hospitals of BJC HealthCare. WashU Medicine has a storied history in MD/PhD training, recently dedicated $100 million to scholarships and curriculum renewal for its medical students, and is home to top-notch training programs in every medical subspecialty as well as physical therapy, occupational therapy, and audiology and communications sciences.Media Inquiries:Public Relations Department, Eisai Co., Ltd.+81-(0)3-3817-5120Eisai Inc (U.S.)Libby Holman　201-753-1945Libby_Holman@eisai.com Copyright 2022 JCN Newswire. All rights reserved. (via SEAPRWire)

29 4 月, 2022

El Salvador Talks Crypto with Policy Makers in Washington

Washington, D.C., Apr 29, 2022 - (ACN Newswire via SEAPRWire.com) - On May 26, 2022, Ambassador Milena Mayorga of El Salvador will address a gathering of 600 innovators, public-sector administrators, legislators, and executives in Washington, DC. She will be sharing the experiences of El Salvador regarding the adoption of Bitcoin as legal tender. Her country leads the world in the national adoption of cryptocurrency.That evening Ambassador Mayorga will be meeting with government blockchain leaders from more than:- 23 Nations- 39 US Government Offices- 18 State & Local Government OfficesThe event is hosted by the US House Congressional Blockchain Caucus and the Government Blockchain Association (GBA). For more information about the event visit www.bit.ly/bseg22-schedule or send an email to events@GBAglobal.orgSource: Plato Data Intelligence: PlatoData.io Copyright 2022 ACN Newswire. All rights reserved. (via SEAPRWire)

12 1 月, 2022

Co-Author of Liechtenstein Blockchain Act Speaks to Government Leaders in Washington

Washington, D.C., Jan 11, 2022 - (ACN Newswire via SEAPRWire.com) - On January 27-28, 2022, Government leaders come to Washington to learn from Liechtenstein's experiences implementing blockchain.In January of 2020, the Liechtenstein Token and Trusted Technology Service Provider Act (TVTG) (known as The Blockchain Act), became enforced as law. With this new law, Liechtenstein became the first country to have a comprehensive regulation of the token economy. Dr. Thomas Dunser, Director of the Office for Financial Market Innovation of Liechtenstein, will be providing insights based on his experience in leading The Blockchain Act, at The Future of Money, Governance, & the Law, held at the National Press Club in Washington DC, and streamed globally. Dr. Dunser will discuss Tokenomics and Crypto-Governance, bringing clarity to the emerging Token Economy. The Token Economy defines a very important development in the digitalization of our economy and society, driven by blockchain technology. Token Economy allows for assets and goods to be represented on a digital transaction system without necessarily relying on a regulated intermediary. Dr. Dunser points out that the Token Economy enables smart contracts to operate, impacting governance beyond the financial services sector.Government policymakers in attendance will be from Washington, El Salvador, Chile, Brazil, Ireland, Jordan, Kuwait, Estonia, Slovenia, Sweden, Australia, Bermuda, and the UK, as well as global governance organizations such as the World Bank, United Nations, the European Parliament, and the Union of Arab Banks.Dr. Dunser's real-world experience in adopting blockchain innovation on a national level will provide a unique opportunity for government legislators to benefit from lessons learned. As this technology continues to land on the forefront of the news, understanding how it has already been implemented will be invaluable for all moving forward. For more information on The Future of Money, Governance, & the Law, go to bit.ly/3ng3KyG. Copyright 2022 ACN Newswire. All rights reserved. (via SEAPRWire)

8 8 月, 2021

Tennis: Italian teen Sinner advances to ATP Washington final

WASHINGTON (AFP) - Italian Jannik Sinner, the ATP's top-ranked teen, advanced to the Citi Open final on Saturday (Aug 7) by ousting US 20-year-old wildcard Jenson Brooksby 7-6 (7/2), 6-1. World number 24 Sinner seeks his third ATP crown after Sofia last November and Melbourne in January. Sinner will play for the Washington hardcourt title on Sunday against the winner of a later semi-final between American Mackenzie McDonald and Japan's Kei Nishikori. At age 19, Sinner became the first Italian finalist in the event's 52-year history. He was the Italian in the Washington final four in a quarter-century. The 2020 French Open quarter-finalist was the only seed in the last four. Three unseeded players hadn't reached the Washington semis since a switch from clay in 1987. Brooksby, ranked 130th but set to crack the top 100 next week, was a runner-up in July at Newport in his first ATP final. Brooksby had not defeated a top-75 foe before this week but rolled over four such players without dropping a set in Washington until facing Sinner. Strong serves and tough rallies spiced the Next Gen showdown, Sinner netting a backhand volley in the 11th game to squander the first break chance, then denying Brooksby on three break points in the 12th game. Sinner took the last four points in the tie-breaker on an ace and service winner followed by wide and netted backhands from Brooksby. In the second set, Sinner broke in the fourth game and sixth games to claim the match in 90 minutes. Sinner won 83 per cent of points on his first serve and 70 per cent of those on his second serve. Sinner, who turns 20 a week from Monday, wants to be part of a new wave of young tennis stars. "I think tennis needs some new guys," he said this week. "I think they are coming slowly, slowly. We are many, many great young players, making a little bit of next generation as well. I think it's nice to see." More on this topic Related Story Tennis: Sherif becomes first Egyptian in WTA final, fired up by Olympics Related Story Tennis: Osaka, Kenin, Swiatek withdraw from WTA Montreal event World number 67 Nishikori, playing his first ATP semi-final since April 2019 at Barcelona, could reach his first ATP final since January 2019 at Brisbane, where he won the most recent of his 12 career titles. Nishikori, 31, was the 2015 Washington champion and 2014 US Open runner-up. World number 107 McDonald, seeking his first ATP final at age 26, reached his only prior semi-final in 2019 at Delray Beach. More on this topic Related Story Tennis: Federer withdraws from Cincinnati, adds to US Open doubts Related Story Tennis: Murray, Korda given wildcards into ATP Cincinnati Masters

4 7 月, 2021

Washington Companies Pays for Bridge Destruction Caused by Their Negligence

LAS VEGAS, NV, Jul 4, 2021 - (ACN Newswire via SEAPRWire.com) - In a recent document, made public under the Washington State Public Records Act (PRA), the Washington Attorney General's Office has provided the results of a lawsuit settlement agreement pertaining to a 2016 bridge strike accident. The public document reveals the details of the settlement between Modern Machinery, a Dennis R. Washington company, and others, regarding a bridge strike of the Chamber Way overpass on Interstate 5.The settlement was due to a lawsuit filed by the Washington State Department of Transportation (WSDOT) against Modern Machinery, a division of Washington Companies and other unrelated firms, involving a tragic and highly preventable bridge strike on July 22, 2016. The State of Washington chose to utilize mediation to free up the backed-up court system. All parties to the lawsuit agreed to mediate the case to reach a palatable dollar amount to pay for the damages to the WSDOT infrastructure based on the different party's contribution to the bridge damage.One of the bases for the WSDOT lawsuit against Washington Companies was the negligence shown while loading two pieces of equipment for transport by one of their Modern Machinery employees, Mr. Tyler Piles. Mr. Piles testified that his negligence of loading the equipment over height was caused by the lack of training provided to him by Washington Companies and Modern Machinery. He testified he had not been instructed when loading a pair of Komatsu excavators to curl the buckets for transport. After the equipment was miss-loaded, which caused the excavators to be over the legal height limit, the flatbed trailer departed the facility. The equipment then struck and destroyed the bridge over the I-5 freeway near Chambers Way, Washington. The severity of the accident to the Chambers Way overpass was of such magnitude that WSDOT felt for safety reasons it was necessary to demolish the remaining portion of the overpass and rebuild a brand-new interchange over the I-5 freeway.The final settlement agreement between the State of Washington and Washington Companies is sparse on other elements, other than the monumental payout by Washington Companies insurance provider to WSDOT for damages to the bridge caused by Washington Companies errors in loading.ETON is a Las Vegas-based premier transportation company serving the Western United States with equipment, professional drivers, and superior on-time service.Washington Companies is a group of individual privately held companies headquartered throughout the United States and western Canada and conducting business internationally. Our purpose is to reliably provide equipment, technology, service, and special expertise that aid our customers to operate more efficiently and more profitably. Our affiliation gives us the ability to interconnect and combine resources and remain highly competitive. The individual success of each Company also empowers a strong sense of social responsibility, realized through corporate charitable activities and programs funded by the Dennis and Phyllis Washington Foundation.Modern Machinery a part of a large consortium of privately held companies collectively known as the Washington Companies, owned by billionaire Dennis R. Washington. Modern Machinery sells and rents high-quality heavy equipment and provides product support to the construction, mining, and forestry industries. The Modern Machinery terminal in Rochester, WA is home to a large staging area for a variety of Komatsu products brought from overseas awaiting shipment to other Komatsu dealers.Komatsu America Corp. is a U.S. subsidiary of Komatsu Ltd., (OTCMKTS: KMTUY) the world's second-largest manufacturer and supplier of earth-moving equipment, consisting of construction, mining, and compact construction equipment.CONTACT:ETON.meMitchell Truman+1 (702) 348 6370http://www.ETON.meEnvironmental Transportation of Nevada, LLC Copyright 2021 ACN Newswire. All rights reserved. (via SEAPRWire)

4 5 月, 2021

NTSB-style Report Blames the Washington Companies in Bridge Destruction

LAS VEGAS, NV, May 4, 2021 - (ACN Newswire via SEAPRWire.com) - A root cause analytical investigation of the causation of a potentially fatal collision of two Komatsu excavators with a locally important bridge on the I-5 freeway in the State of Washington was executed recently. Mr Jeff Guzzetti, former Director, Accident Investigation Division of the Federal Aviation Administration, and former Deputy Director, Regional Office of the U.S. National Transportation Safety Board (NTSB), provides an in-depth review of the accident which occurred July 22, 2016. The goal of Mr Guzzetti's investigation is to determine the root cause of the bridge strike.Mr Guzzetti was called upon to utilize the forensics-style methodology employed by his former employer, the US National Transportation Safety Board (NTSB), with a high degree of professional integrity and impartiality in determining the causal events behind the accidents, and finding the parties with the most responsibility in the bridge strike.Quoted from Mr Guzzetti's report under probable cause:"Based on my review of available material, I have determined that the probable cause of this accident is (1) the shipper's improper loading of the excavator, and failure to prevent the departure of the truck in an over-height state. Factors contributing to the cause are (2) the lack of adequate training and protocols by Modern Machinery."The list of other parties that may have contributed to the accident listed in this report are, The State of Washington Department of Transportation, the Federal Motor Carrier Safety Administration, and ETON.The shipper of the two excavators was the Modern Machinery company, a subsidiary of the Washington group of companies. Part of the material Mr Guzzetti used was the deposition of the Washington company employee, Mr Piles, where under sworn oath he testified that they had never been trained to curl the excavator's bucket as required by the manufacturer for the transport of these excavators in question.ETON is a Las Vegas-based premier transportation company serving the Western United States with equipment, professional drivers and superior on-time service.The Washington Companies are a group of individual, privately held companies headquartered throughout the United States and western Canada and conducting business internationally, whose purpose is to reliably provide equipment, technology, service, and special expertise that aids customers to operate more efficiently and more profitably. Our affiliation gives us the ability to interconnect and combine resources and remain highly competitive. The individual success of each Company also empowers a strong sense of social responsibility, realized through corporate charitable activities and programs funded by the Dennis and Phyllis Washington Foundation.Modern Machinery is part of this large consortium of privately held companies, collectively known as the Washington Companies, owned by billionaire Dennis R. Washington. Modern Machinery sells and rents high-quality heavy equipment and provides product support to the construction, mining, and forestry industries. The Modern Machinery terminal in Rochester, WA is home to a large staging area for a variety of Komatsu product brought from overseas awaiting shipment to other Komatsu dealers.Komatsu America Corp. is a U.S. subsidiary of Komatsu Ltd. (OTCMKTS: KMTUY) the world's second-largest manufacturer and supplier of earth-moving equipment, consisting of construction, mining and compact construction equipment.CONTACT: ETON.meMitchell Truman+1 (702) 348 6370http://www.ETON.meEnvironmental Transportation of Nevada, LLC Copyright 2021 ACN Newswire. All rights reserved. (via SEAPRWire)

3 5 月, 2021

Blockchain & Liberty for All

Washington, D.C., May 3, 2021 - (ACN Newswire via SEAPRWire.com) - Live from Washington DC, GBA will host a virtual gathering of members to celebrate the accomplishments of 2020 and plan our trajectory going forward. Join us, June 18-19, as the GBA hosts, BLOCKCHAIN AND LIBERTY FOR ALL, streaming virtually to cities around the world.In commemoration of June 19th, also known as Freedom Day, Juneteenth is a U.S. holiday celebrating the emancipation of African Americans still held in slavery in Texas in 1865, more than two years after the Emancipation Proclamation had officially outlawed slavery. This 2-year delay came from a deliberate withholding of the news of freedom, chaining thousands of slaves with a lie. Today we have an abundance of news, 24/7, on multiple channels. But are we getting the truth, or is it fake news? Without verification, can we trust the data? Blockchain is a specific type of database in which blocks of data are chained together in chronological order, immutable, irreversible, and viewable to anyone. No data goes into a block until the entire community sees it and verifies it. Blockchain as a system can provide verification, trust, and liberty for all. Hence the theme of this year's GBA annual meeting, Blockchain and Liberty for All.The Government Blockchain Association, GBA, is a global business association with chapters in 120 cities around the world. In only a few short years, the GBA has risen from a local meetup to an international association of blockchain innovators and government policy makers with over 50 Working Groups including:- Acquisition Management- Big Data- Cannabis- Cybersecurity- Education and Training- Emergency Management- Financial Regulatory- Gaming- Grants- Intellectual Property- Land Titling- Smart Cities- Space- Supply Chain- Voting, and More...Leaders from GBA Africa, Middle East, Asia-Pacific, Europe, South America, US, Canada, and India will give yearly updates. Eric Guthrie, Esq., GBA Director of Training and author of Diversify or Die, will give a Keynote on 'Journey to Freedom'. Technology, the Token, Fair and Honest Elections, and Blockchain and Equal Opportunity will all be discussed."Political freedom must be accompanied by economic freedom for people to be truly free. Blockchain Technology is a new frontier in the economic landscape." says Gerard Dache, Executive Director, GBA.Blockchain technology does not discriminate between color, gender, age, nationality, or background (education). This new technology presents an opportunity for all who want to embrace it. Join GBA on June 18-19 as we discuss our yearly update. For more information go to Blockchain & Liberty for All (www.gbaglobal.org/event/blockchain-liberty-for-all)Source: Plato Data Intelligence (https://zephyrnet.com/blockchain-liberty-for-all/) Copyright 2021 ACN Newswire. All rights reserved. (via SEAPRWire)